Applying Pharmacogenetics

To apply Pharmacogeneticsit is the basis for a personalized medication, and its correct application avoids adverse reactions due to toxic reactions.

• It is not to put obstacles to the free prescription of doctors. It is helping to make a personalized prescription, depending on the genetics of each patient. Its purpose is to achieve better results, fewer adverse effects and fewer therapeutic failures.That is to pass from the “established protocol equal for all”, to the personalized treatment based on possible genetic changes in the patient.Certain genetic polymorphisms can modify, at the individual level, the general expected action of some drugs, or alter their response due to different consumer products or life habits, and in some cases, the doses to prescribe or replace the planned medication must be modified.It is simply a matter of consulting in aPharmacogenetics softwarethe medication taken by the patient and to be prescribed. The program will inform, if medication and dosage is correct, or should change the medication to prescribe or change the dose, in order to avoid the patient therapeutic failures, or lack of action of the drug, or adverse effects more or less serious .There are many studies that scientifically endorse Pharmacogenetics improving the quality of care. At the same time,it avoids hospital admissions, prevents adverse effects, avoids deaths, and saves many expenses to the health system.A study conducted in the USAby clinical physicians of the pharmacy service of a hospital center, contrasted the effectiveness of treatments guided by pharmacogenetic criteria, in relation to those applied following conventional protocols:
• 65% fewer new visits due to no improvement or adverse effects of the medication in the first 30 days and 48% less after 60 days.
• A 62% reduction in admissions to the emergency room due to side effects of medication at 30 days and 58% less at 60 days.Even though numerous publications show that applying Pharmacogenetics influences clinical and economic results, with an advantageous cost / benefit ratio.It is clear in the statistics, according to theEuropean Union(effects by ADR) and official data of the FDA, that in the USA caused in 2014, 123,000 deaths and 807,000 admissions to the emergency room due to drug interactions,in patients correctly prescribed according to the protocols.

Dr. Juan Sabater-TobellaEuropean Specialist in Clinical Chemistry and Laboratory Medicine (EC4)Member of the Pharmacogenomics Research NetworkMember of the International Society of Pharmacogenomics and Outcomes ResearchPresidente de EUGENOMIC®

Last modified: Mar 13, 2018 @ 10:56 am

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Last modified: Nov 20, 2018 @ 5:26 pm